Showing posts with label vaccine. Show all posts
Showing posts with label vaccine. Show all posts

10 June, 2011

Source of e. coli Outbreak Discovered; Meningitis Vaccine Reduces Cases; Fungal Infection Strikes Joplin, MO

Germany: It’s the sprouts. We mean it this time.
First it was cucumbers (Spanish), then it was sprouts. Then it was cucumbers (German) and now officials say it truly was the sprouts. Although lab tests failed to find the E. coli on plants at the farm which produced the sprouts, the strain was isolated on leftover sprouts from a family which became ill. At the moment, the European Centre for Disease Prevention and Control reports that 3086 people became ill. Media reports state 33 have died (all German except for 1 Swede). The United States and Canada also reported cases suspected to be associated with the outbreak. Over a quarter of cases experienced the severe form of the infection,  Hemolytic Uremic Syndrome. This strain has been unusually severe, with doctors noting neurologic damage in many patients.

In the end, traditional epidemiological studies examining foods consumed and events attended by both sick and healthy individuals showed many of the infected ate at restaurants and cafeterias supplied by one organic sprout farm. From there, investigators were eventually able to track down sprouts that test positive for the strain. Those interested in reading about the methods and challenges of investigating an outbreak of foodborne illness may enjoy this post.

The outbreak has been devastating to farmers. While Spanish cucumber farmers were the first to feel the impact, consumers soon began to avoid all produce as no single source was quickly identified.

The German E. coli outbreak has sparked increased news reporting of E. coli cases, even those not linked to the outbreak. The Netherlands, Thailand and Finland all reported finding E. coli. In Tennessee, a two year old girl has died and 8 are believed to be ill from E. coli.

Meningitis Vaccine Project (MVP) Reduces Cases
World Health Organization (WHO) data on the MenAfriVac vaccine distributed in Meningitis Belt countries show a massive decrease in cases in Burkina Faso, Mali and Niger.  The Serum Institute, based in India, developed MenAfriVac against meningitis A, which has been very common throughout the infamous Meningitis Belt.  They began distribution for 50 U.S. cents a dose six months ago.  In the 2011 meningitis season, Burkina Faso confirmed 4 cases (compared to 66 this time in 2010), Niger also reported 4 cases (compared to 219 last year) and Mali had no reported cases (10 cases the previous year). These dramatic decreases are promising for the fight against meningitis. The MVP hopes to immunize 250 million people in Africa between 2010 and 2015.

Rare Fungal Infection Strikes Joplin Tornado Survivors
On May 22, 2011 much of Joplin, Missouri was destroyed when an EF-5 tornado ripped through the small town killing 151 in its path. (The EF-5 rating is the highest rating on the Enhanced Fujita tornado scale.) The storm ravaged a one-mile wide, thirteen-mile long path through Joplin, destroying 8000 homes and apartment complexes, and leaving thousands homeless.  The tornado that hit Joplin, MO is the deadliest twister to strike in the United States since modern record keeping began in 1950.

As if the people of Joplin haven’t suffered enough, a new threat has emerged, as a potentially lethal fungal infection has been contracted by at least 9 tornado survivors, killing 3. (The Jasper county coroner has so far stated that 1 was killed as a direct result of the fungal infection while the other two victims had other medical conditions that could have contributed to their deaths.)

Zygomycosis (also known as mucormycosis) is caused when commonly present fungi, found in soil and decaying vegetation, becomes embedded under the skin. These secondary skin-fungal infections are sometimes seen in survivors of mass trauma where multiple injuries and skin lacerations are treated as quickly as possible in makeshift emergency shelters (such as the 2004 Indonesian tsunami).  Doctors began seeing patients in Joplin with fungal infections a week after the tornado. Patients have visible mold growing in their wounds, and surgery is typically required to remove the dead tissue. Zygomycosis can also invade the brain, lungs, or sinuses, and generally kills half of its victims. Despite the severity of zygomycosis, it should be stressed that people should not panic. The infection does not spread from person to person and does not invade normal, intact skin.

18 May, 2011

Hope for HIV Vaccine; Ebola Strikes in Uganda

HIV/AIDS Vaccine Shows Promise
A new HIV/AIDS vaccine may be in the works as research at an Oregon University has shown to prevent virus replication in monkeys.

Louis Picker, a researcher at Oregon Health Sciences University (OHSU), specifically in the Vaccine and Gene Therapy Institute (VGTI) has been working on developing a HIV/AIDS vaccine from genetically modified cytomegalovirus (CMV).  CMV is a member of the Herpesviridae family and is most commonly associated with salivary glands in the body. CMV was used in this vaccine development because most people are already infected with CMV, although they show little to no symptoms. In addition, once an individual is infected with CMV they carry the virus for the rest of the life.

This new vaccine was tested on rhesus macaque monkeys at Oregon National Primate Research Center in Beaverton, Oregon. All of the moneys were infected with Simian Immunodeficiency Virus (SIV), the monkey form of Human Immunodeficiency Virus (HIV). This vaccine prevented infection in thirteen of the twenty-four monkeys who were originally infected with SIV for more than one year. These thirteen monkeys’ bodies controlled the replication of SIV to the point that highly sensitive tests could not find any traces of the virus.

These results are extremely promising and hopeful for developing a vaccine for humans. The next step for Dr. Picker and his team will be to develop the current vaccine for human testing.  If successful, this vaccine could prevent thousands of people in the United States from being infected each year.

Ebola Hits Uganda
Last week, a twelve-year old girl from Luwero died in the Bombo Military Hospital about 60 kilometers outside of Uganda’s capital, Kampala, from the deadly Ebola virus. Ebola was confirmed only after the girl’s blood sample tested positive for Ebola at the CDC in Atlanta.

Ebola virus is a viral genus in the Filoviridae family that causes Ebola hemorrhagic fever, which presents itself in patients by sudden symptoms of fever, malaise, muscle pain, headache, and pharynx inflammation. Rashes, red eyes, hiccups, and internal and external bleeding are also common in those suffering from Ebola.  There are four types that affect humans: Ebola-Zaire, Ebola-Sudan, Ebola-Ivory Coast and Ebola-Bundibugyo virus. Unfortunately, there is no known cure for Ebola and the fatality rate is about 85%.

Uganda’s last outbreak of Ebola occurred in 2007, but wasn’t officially declared until February 20, 2008. There were 148 people ill and 37 of them died. In hopes of preventing a similar situation, nearly 40 people who may have been exposed to the young girl who died have been quarantined and monitored for any early Ebola symptoms. Government officials have said visitors to Uganda do not need to worry about possible contact with the virus since these people were quarantined early.

25 November, 2009

H1N1 (swine flu) Weekly Highlights: November 18 - 24, 2009


Somalia reported its 1st cases of H1N1, while Lithuania, Switzerland, Macedonia, Maldives, Madagascar, Romania, Estonia, and Denmark reported their 1st deaths.

The World Health Organization (WHO) tallied over
525,000 H1N1 cases and about 6,750 deaths worldwide.

As the US Centers for Disease Control (CDC) reported
decreased flu activity in all regions of the US, the WHO noted the eastward spread of H1N1 across Europe and Asia.

Four H1N1 related deaths have been reported among pilgrims for the
Hajj which starts on the 26th.

As immunization campaigns continue in over
40 countries, the WHO reiterated the safety of the H1N1 vaccine, adding that investigation into 40 post-vaccine deaths (among the over 65 million doses given in 16 countries alone) has found no association between the vaccine and the documented fatalities.

In a development
not unexpected among experts, Tamiflu-resistant H1N1 clusters emerged among hospitalized patients with severe underlying medical conditions in Wales and North Carolina.

Norwegian scientists announced detection of a mutated H1N1 virus that may allow infection deeper into the airways leading to more severe disease. Hong Kong then reported the same mutation, and Finland saw it in July. The WHO subsequently stated that a similar mutation had been observed in six other countries as early as April. Despite the mutations, the H1N1 vaccine is still effective.

A single batch of H1N1 vaccine in Canada has been pulled after a higher than usual rate of
severe allergic reactions.

CDC has confirmed a rare
second H1N1 infection in the same individual in West Virginia.

In a study of
US Army personnel, those who received the 2008 seasonal flu vaccine were 45% less likely to contract H1N1 and 62% less likely to be hospitalized if infected.


Photo source:
http://www.examiner.com/x-29691-Boulder-Healthy-Living-Examiner~y2009m11d24-H1N1-Swine-Flu-Symptoms-Is-someone-on-your-flight-showing-flu-signs

04 November, 2009

H1N1 (swine flu) weekly highlights: October 28 - November 3, 2009

Afghanistan, Ukraine, Moldova, Croatia, Belarus, Slovenia, Austria, and the Canadian provinces of Newfoundland and Yukon reported their first H1N1 deaths.

The World Health Organization (WHO) reported the number of
global H1N1 deaths jumped to over 5,700 worldwide.

In other statements, WHO reiterated that the
vaccines are safe, that one dose is sufficient for adults and children over 10, and that pregnant women should be vaccinated since they are a high-risk group.

Researchers at the annual meeting of the
Infectious Diseases Society of America reported that influenza vaccination of pregnant women was "85 percent effective in preventing hospitalization in their infants under 6 months of age." The study also indicated babies of vaccinated women were bigger, healthier and less likely to be premature.

Following last week's declaration of a national emergency in the US,
New York state and the city of Philadelphia made similar declarations. This allows hospitals and local governments freedoms from certain restrictions during the emergency. HHS Secretary Sebilius suspended additional regulations relating to H1N1 treatment.

Long lines and vaccine shortages plagued H1N1 vaccine clinics throughout the
United States and Canada.

As the number of
US children who have died of H1N1 climbed to 114 and 48 states reported widespread flu, the CDC noted that only half of people who most need immediate treatment for H1N1 swine flu are actually seeking it.


Photo courtesy of: http://www.latimes.com/features/health/la-me-swine-flu-clinics4-2009nov04,0,3665600.story?track=rss